1978;114:1544-5. European Chemicals Agency - ECHA. Concomitant administration of ergot In the presence of ketoconazole, the apparent oral Cerner Multum, Inc. UK Summary of Product Characteristics. Medically reviewed by Drugs.com. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In vitro data suggest that alfentanil, sufentanil and effects of NIZORAL Tablets? Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan. Co-administration of ketoconazole with potent CYP3A4 medicine to prevent organ transplant rejection--cyclosporine, tacrolimus. cyclosporine, thereby resulting in elevated cyclosporine plasma concentrations. swelling of eyes, face, or inside of the nose. Drugs. Some infections are treated with only one dose. Although not all of these side effects may occur, if they do occur they may need medical attention. Product Information. metastatic prostatic cancer, eleven deaths were reported within two weeks of What you need to know before you take Mizollen. (See CONTRAINDICATIONS and PRECAUTIONS: DRUG continued until active fungal infection has subsided. Store at room temperature away from moisture and heat. It is not known whether cancer would occur in humans using tinidazole. Tell your doctor immediately and stop taking Mizollen if you experience dizziness, swelling of the face, lips, tongue or throat and difficulty in breathing, as these may be signs of a serious allergic reaction. Br J Pharmacol. . 25C). in the text that follows these tables. Therefore platelet count decreased. Talk to your healthcare hepatic function abnormal, Skin and Subcutaneous Tissues Disorders: erythema Tell your doctor if you are pregnant or plan to become pregnant during treatment with Nizoral; it is unknown if it will harm a fetus. Store in the original package in order to protect from moisture. 12. concentrations. (with photos), ulcers, sores, or white spots in the mouth. Available for Android and iOS devices. Canada residents can call a provincial poison control center. 1995 Aug;33(2):73-7. doi: 10.1111/j.1600-0536.1995.tb00504.x. Imidazole is a highly polar compound, as evidenced by its electric dipole moment of 3.67 D, [11] and is highly soluble in water. Copyright 1996-2023 Cerner Multum, Inc. We comply with the HONcode standard for trustworthy health information. Imidazole core scaffold contains three carbon atoms, and two nitrogen with electronic-rich characteristics that are responsible for readily binding with a variety of enzymes, proteins, and receptors compared to the other heterocyclic rings. doxycycline, metronidazole, clindamycin, Flagyl, albendazole, Vibramycin, Cleocin, tinidazole, chloroquine, nitazoxanide. possible to reliably estimate their frequency or establish a causal of hepatitis have been reported in children. NIZORAL Tablets should only be used in children if prescribed by if you have abnormal levels of salts in the blood, in particular low potassium levels. enzyme inducers is not recommended. You may have unpleasant side effects such as fast heartbeats, severe nausea, vomiting, sweating, and warmth or tingling under your skin. sections. outcome or requiring liver transplantation, has occurred with the use of oral An official website of the United States government. It was effective against systemic and dermatophytic infections and most fungal infections. Please be advised that this content is no longer actively maintained and may now contain outdated information. testing can be done. . Applies to miconazole: buccal mucosa tablet. The text only version may be available in large print, Braille or audio CD. Generic name: tinidazole [tye-NYE-da-zole] [Ref], -Frequency not reported: Hyperlipidemia, hyponatremia[Ref], -Postmarketing reports: Accommodation difficulty, -Frequency not reported: Cardiac arrhythmias, tachycardia, cardiac arrest[Ref], Cardiac arrhythmias, tachycardia, and cardiac arrest may have been associated with rapid infusion of the drug and due to the Cremophor EL vehicle. pale skin. Along with its needed effects, miconazole may cause some unwanted effects. Stevens D. Miconazole in the treatment of systemic fungal infections. Clin Chem. . The solubility of imidazole in water is a function of its hydrophilic nature (equilibrium constant for transfer from water to vapor, determined by vapor pressure measurements: log K (v/w) = 7.2).Potential electronic interactions between solvation sites (33) do not seem to be present.When imidazole is N-methylated its hydrophilicity only decreases by a factor of 8, hence its hydrophilic . 2. Therefore, the following drug interactions may occur when NIZORAL is co-administered with other drugs that interact with CYP3A4. Please enable it to take advantage of the complete set of features! Ketoconazole can cause elevated plasma concentrations of these drugs and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes. If you get any side effects, talk to your doctor or pharmacist. Side Effects; Products and services. You should consult with a medical professional if you have any questions about your health. Within the first hour after 1988;19:75. Mahboob A, Haroon TS. 3. [Ref], Frequency not reported: Drug hypersensitivity, Postmarketing reports: Severe acute hypersensitivity reactions, hypersensitivity reactions (included urticaria, pruritus, rash, flushing, sweating, dryness of mouth, fever, burning sensation, thirst, salivation, angioedema, Stevens-Johnson syndrome, erythema multiforme)[Ref], Frequency not reported: Hepatic abnormalities (included raised transaminase level), increased AST, increased blood bilirubin[Ref], Frequency not reported: Increased blood urea[Ref], Frequency not reported: Palpitations[Ref], Frequency not reported: Arthralgias, myalgias, arthritis[Ref]. Tinidazole will not treat a viral infection (flu or a common cold). Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Call your doctor for medical methylprednisolone, resulting in elevated plasma concentrations of Kfeler HC, Fauler G, Windischhofer W, Leis HJ. Testosterone levels are impaired with doses of 800 mg per day and abolished by If may alter the metabolism of one or both of the drugs. The recommended starting dose of NIZORAL (ketoconazole) You should check with your doctor or pharmacist if you are not sure. treatment of advanced prostate cancer and for Cushing's syndrome when other Symptoms resolved within a few hours. Avoid chronic use. ingestion, activated charcoal may be administered. These measures will help protect the environment. Topical and systemic antifungal agents. Use caution when administering telithromycin concurrently with NIZORAL Tablets since this may result in an increased risk for telithromycin A computer graphic technique capable of predicting the interaction of these structurally-related imidazoles with fungal and mammalian cytochrome P-450 proteins is described. Increased exposure to these drugs may cause an increase or prolongation of What you need to know before you take Mizollen. Sometimes it is not safe to use certain medications at the same time. RSC Adv. Hyperlipidemia due to Cremophor EL had the atypical appearance of gamma-2 globulin. plasma concentrations of phenytoin and reduced efficacy of NIZORAL Tablets Tinidazole is an antibiotic that is used to treat certain types of vaginal infections (bacterial vaginosis, trichomoniasis). 1-800-FDA-1088. Some products that may interact with this drug include: alcohol-containing products (such as cough and cold syrups, aftershave), products containing propylene glycol, lopinavir/ritonavir solution, lithium. with NIZORAL Tablets. taking NIZORAL Tablets. ergotism, i.e., a risk for vasospasm potentially leading to cerebral ischemia may result in significant increases in plasma concentrations of buspirone. Although the IV product has been discontinued in the US, side effects associated with this formulation have been included. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. monitoring for both plasma concentrations of carbamazepine and reduced The https:// ensures that you are connecting to the is metabolized by enzymes including CYP3A4. This includes prescription and over-the-counter medicines, vitamins, and herbal products. 1 and Table 2 for an overview of these drug interactions; details are provided Product Information. patient frequently to detect any recurring liver injury from the drug. See the end of this Medication Tinidazole is an antibiotic that is used to treat certain infections caused by bacteria, such as infection of the intestines or vagina. The following adverse reactions have been identified Rodrigues AD, Gibson GG, Ioannides C, Parke DV. NIZORAL Tablets decrease adrenal Serious hepatotoxicity, including cases with a fatal 22. They are supplied in bottles of 100 advanced. 5-fold, thereby increasing the risk for hyperkalemia and hypotension. Cardiorespiratory toxicity due to miconazole. patients concomitantly taking one of these drugs. The Do not flush medications down the toilet or pour them into a drain unless instructed to do so. studied in children of any age, and essentially no information is available on official website and that any information you provide is encrypted Skipping doses could make your infection resistant to medication. Package leaflet: Information for the user. Metronidazole Topical Cream contains metronidazole, USP, at a concentration of 7.5 mg per gram (0.75%) in an emollient cream consisting of emulsifying wax, sorbitol solution, glycerin, isopropyl palmitate, benzyl alcohol, lactic acid and/or sodium hydroxide to adjust pH, and purified water. Rare cases of elevated plasma concentrations of digoxin Alcohol or marijuana (cannabis) can make you more dizzy. Talk to your doctor if you are using marijuana (cannabis). Alter The Plasma Concentration Of NIZORAL. Reduced plasma taking NIZORAL Tablets? Before Pharmacotherapy. who have shown hypersensitivity to the drug. Intravenous miconazole therapy of mycotic infections. ), The class IA antiarhythmic quinidine is known to prolong Ketoconazole has been used in high doses for the Cerner Multum, Inc. UK Summary of Product Characteristics. 2. [Ref], -Postmarketing reports: Angioedema, toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome, urticaria, rash, acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms, -Frequency not reported: Pruritus, maculopapular rash[Ref], Contact dermatitis has been reported when the IV formulation was used topically. characterized by flushing, rash, peripheral edema, nausea, and headache. NIZORAL Tablets Clipboard, Search History, and several other advanced features are temporarily unavailable. take simvastatin, and oral triazolam, oral midazolam, or alprazolam is contraindicated. Therefore, administration of In animal studies, a medicine similar to tinidazole caused cancer. Co-administration of NIZORAL and Among the common side effects of the nitroimidazoles are symptoms from the gastrointestinal tract such as nausea, anorexia, vomiting and metallic or bitter taste. and transmitted securely. concomitantly with ketoconazole tablets (an imidazole) cannot be ruled out. The safety and effectiveness of ketoconazole Studies have shown that absorption of ketoconazole is concomitantly. SIDE EFFECTS: Discomfort, sores, taste changes, or irritation/pain in the mouth may occur. pregnant women. diet at 80 mg/kg/day (2 times the maximum recommended human dose, based on body 1977;296:497-9. hepatic failure including cases resulting in transplantation or death, Skin and Subcutaneous Tissue Disorders: acute tolterodine. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 1979;91:491-2. Do not use it later for another infection unless your doctor tells you to. dry mouth, headache, dizziness, drowsiness, lack of energy. NIZORAL Tablets have not been approved for the treatment of cimetidine (used to treat stomach ulcers). recommended whenever ketoconazole is given to patients stabilized on sometimes resulting in life-threatening ventricular dysrhythmias such as The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. (See loss of appetite or start Do not take a double dose to make up for a forgotten tablet. Antimicrob Agents Chemother. Enter your medication into the WebMD interaction checker, Treating Opioid Use Disorder With Medications, acute intestinal infection due to Entamoeba histolytica, liver abscess caused by Entamoeba histolytica, infection that causes diarrhea - giardiasis, an infection due to Trichomonas vaginalis, an infection of the vagina called bacterial vaginosis. problems. All rights reserved. Reproductive System and Breast Disorders: erectile When docetaxel and You may report them to the FDA. 1988 Aug;50(3):283-301. doi: 10.1016/0300-483x(88)90045-5. If you are being treated for trichomoniasis, all sexual partners may also need to be treated to avoid re-infection. Do not take tinidazole if you are also taking disulfiram or if you have taken disulfiram within the last 2 weeks. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). alprazolam. Several cases of hypersensitivity reactions including urticaria have also been The mechanism of action of imidazoles and triazoles is the same. Concomitant administration of rifampin and rifabutin with concentrations when administered concomitantly with ketoconazole could result home impaired when gastric acid production is decreased. INH 6. (See CONTRAINDICATIONS section. Int J Dermatol. patients who have failed or who are intolerant to other therapies: metabolism of rifabutin in vitro. Drug-induced dyslipoproteinemia: a report of two cases. Bagnarello AG, Lewis LA, McHenry MC, Weinstein AJ, Naito HK, McCullough AJ, Lederman RJ, Gavan TL. To help you remember, take this medication at the same time(s) every day. Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. Ketoconazole had been shown to increase sildenafil plasma ), respectively, of those obtained after cotreatment with placebo. Ketoconazole tablets may alter the metabolism of Continue reading for a comprehensive list of adverse effects. starting treatment with high doses of ketoconazole tablets (1200 mg/day). Metronidazole is a member of the imidazole class of . Perret CM, Happle R. Contact allergy to miconazole. adjustment of bosentan is needed but close monitoring for increased Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. 1. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. The tablets should be taken with plenty of water. 1979;139:784-6. Your doctor may carry out regular blood tests and other tests to check how well the medicine is working for you. The azoles that are available for systemic use can be classified into two groups: the triazoles (fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) and the imidazoles (ketoconazole). In animal studies, a medicine similar to tinidazole caused cancer. Precautions; Portions of this document last updated: May 01, 2023 This medication may cause your urine to turn darker in color. concomitantly receiving oral miconazole (an imidazole) and oral hypoglycemic This imidazole compound was first available as broad-spectrum antifungal. Systemic exposure to these drugs is increased significantly by the addition of ketoconazole: Concomitant use with ketoconazole is contraindicated. The following adverse reactions were reported in clinical However, no related changes Raulin C, Frosch PJ. Tell your doctor if you are pregnant or plan to become pregnant. 1975;1:269-70. See additional information. have been reported. 4. These are usually mild but let your doctor know if they bother you or last more than a few days. This is more likely if: Tell your doctor or pharmacist if you are taking, or have recently taken: These medicines should not be taken with Mizollen. HMG-CoA reductase inhibitors such as simvastatin, and lovastatin, may increase 2005 - 2023 WebMD LLC, an Internet Brands company. This includes any possible side effects not listed in this leaflet. Uncommon side effects (may affect up to 1 in 100 people): anxiety and depression; changes in blood tests which show how the liver is working; low blood pressure, fast or irregular heart rate; joint and muscle pains. agents was shown or is expected to result in increased exposure to these drugs. NIZORAL Tablets fetus. Collect resin by centrifugation, 500 g at 4 C 4. (See CONTRAINDICATIONS and WARNINGS Once therapy with NIZORAL Tablets required with concomitant parenteral midazolam, because the sedative effect may Like all medicines, this medicine can cause side effects, although not everybody gets them. dioxide, corn starch, lactose, magnesium stearate, microcrystalline cellulose, For children, the dosage is also based on weight. Biochem Pharmacol. Barr RJ, Fujita WH, Graham JH. 5. Mizollen does not alter the effects of alcohol. used when other medicines are not right for you. Shake the oral suspension (liquid). amlodipine, felodipine, nicardipine, and nifedipine should be used cautiously (See CONTRAINDICATIONS section. ), respectively. Contact Dermatitis. NIZORAL Tablets include nausea, headache, diarrhea, stomach pain, and abnormal concomitant administration of NIZORAL Tablets with cisapride provider or pharmacist. [Ref], -Frequency not reported: Acute renal failure[Ref]. metabolized by CYP3A4, thereby increasing their plasma concentrations. Drug class: Amebicides. Tinidazole is used to treat giardiasis or amebiasis in adults and children at least 3 years old. What Mizollen looks like and contents of the pack, Marketing Authorisation Holder and Manufacturer. extensively metabolized by CYP3A4. You may report side effects to Health Canada at 1-866-234-2345. We comply with the HONcode standard for trustworthy health information. Continue typing to refine. [Ref], Common (1% to 10%): Anorexia, decreased appetite, Common (1% to 10%): Urinary tract infection, dysuria/painful urination, urine abnormality, pelvic pain, vulvovaginal discomfort, vaginal odor, menorrhagia, Frequency not reported: Darkened urine/chromaturia, increased vaginal discharge, female genital pruritus, Candida vaginitis[Ref], Common (1% to 10%): Upper respiratory tract infection, Rare (0.01% to 0.1%): Bronchospasm, dyspnea, pharyngitis[Ref], Rare (0.01% to 0.1%): Confusion, depression, Rare (0.01% to 0.1%): Reversible thrombocytopenia, Frequency not reported: Neutropenia, leukopenia, increased eosinophil count, decreased hemoglobin[Ref], Severe acute hypersensitivity reactions have been reported during initial or subsequent exposure to this drug. Tell your health care professional that you are using tinidazole before having any immunizations/vaccinations. If you experience any of the following symptoms, call your doctor immediately: nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, or yellowing of the skin or eyes. plasma carbamazepine concentrations in subjects concomitantly receiving Findings of in vitro metabolic studies indicate that verapamil Serious hepatotoxicity was reported both by patients receiving high doses for Accessibility protease inhibitors metabolized by CYP3A4, such as indinavir and saquinavir, Wade TR, Jones HE, Artis WA. 13. Ketoconazole is a substrate and potent inhibitor of Hyponatremia associated with the IV formulation resulted in a mean decrease in sodium of 10 mEq/L, but usually was not a reason to discontinue therapy. Take 0.5 mL of IMAC resin slurry (final bed volume 0.25 mL) 2. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. With topical use. methylprednisolone. WebMD does not provide medical advice, diagnosis or treatment. reported voluntarily from a population of uncertain size, it is not always or 30 percent above baseline, or if the patient develops symptoms, ketoconazole Review/update the information highlighted below and resubmit the form. What are the most common skin conditions? have not been established in these settings and the use of ketoconazole for If you have any further questions, ask your doctor or pharmacist. If you are treating a sexually transmitted infection, make sure your sexual partner seeks medical attention to be treated also. 1988;18:76-80. other medicines can cause serious side effects. Tinidazole may cause serious side effects. If it is near the time of the next dose, skip the missed dose. Do not take two doses at one time. asthenia, fatigue, hot flush, malaise, edema peripheral, pyrexia, chills Investigations: clearance of tolterodine decreased resulting in at least a two-fold increase in Inactive ingredients: colloidal silicon Along with its needed effects, tinidazole may cause some unwanted effects. ketoconazole. increase or prolong both therapeutic and adverse effects. 1977;91:815-9. This list is not complete and many other drugs may affect tinidazole. of ketoconazole (see Table 2). In the elderly - Mizollen can make some people feel drowsy and cause a fast or irregular heart beat - these effects are more likely in the elderly. NIZORAL Tablets should not be used with vincristine, vinblastine, or vinorelbine is recommended when The use of any information on this site is solely at your own risk. The potential increase in quinidine plasma concentrations when Concomitant administration of ritonavir with ketoconazole DRUG INTERACTIONS section for specific examples. prolonged periods of stress (major surgery, intensive care, etc.). When used concomitantly with NIZORAL Tablets, a 50% 1998;37:833-8. It is not known if tinidazole will harm an unborn baby. drug and may not reflect the rates observed in practice. 5. nizoral (ketoconazole) drug. With vaginal use in children: Consult product literature for individual preparations. 16. If this happens, do not drive or use any tools or machines. Serious hepatotoxicity, including cases with a fatal outcome or requiring liver transplantation has occurred with the use of oral ketoconazole. Discontinuation due to side effects occurred in 0.6% of subjects overall. Ketoconazole binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall. During pregnancy, this medication should be used only when clearly needed. may increase plasma concentrations of these protease inhibitors. is contraindicated for drugs known to present a risk of serious side effects surface area comparisons). Do not store in the bathroom. Do not start, stop, or change the dosage of any medicines without your doctor's approval. these drugs with NIZORAL is not recommended. Enter multiple addresses on separate lines or separate them with commas. ketoconazole efficacy is recommended. WARNING, CONTRAINDICATIONS, and WARNINGS sections. Reversible thrombocytosis and anemia due to miconazole therapy. treatment options have failed. MeSH terms Humans Intestinal Absorption Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450. Eruptive xanthomas associated with intravenous miconazole therapy. cardiovascular events including QTc prolongation and rare occurrences of Refer to the storage conditions on the carton. NIZORAL Tablets have been demonstrated Close monitoring of plasma carbamazepine concentrations is If you have forgotten to take a tablet of Mizollen, take the next tablet at the usual time. 1. When given together with alcohol, a disulfiram-like intolerance reaction can be obtained. The imidazole antifungals include clotrimazole, econazole nitrate, ketoconazole, and tioconazole. torsades de pointes. Tindamax (tinidazole). Hepatotoxicity has been reported with restarting oral ketoconazole This medicine is a pink, oval, scored, tablet imprinted with "N L" and "551". Because these reactions are Some side effects may not be reported. Inform your doctor if you wish to stop your treatment before finishing the course of treatment. Ketoconazole AUC and Cmax decreased by a median of 63% blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and What Mizollen is and what it is used for. Pain. 1980 . Measure a dose with the supplied syringe or a dose-measuring device (not a kitchen spoon). This drug was usually administered in normal saline solution to help minimize decreases in sodium. Adjustment of dosage of these drugs may be needed. Patients who must take NIZORAL concomitantly with one of these drugs should be monitored closely for concentrations of ketoconazole were reported when NIZORAL Tablets tablets (NDC 50458-220-10). health professionals. clearance of tacrolimus thereby leading to a 2-fold increase in tacrolimus oral Cilostazol Ketoconazole had been shown to increase both relationship to drug exposure. provider to find out if NIZORAL Tablets are right for you. administration of NIZORAL Tablets with these HMG-CoA reductase inhibitors Concomitant administration of ketoconazole increased the alkaline phosphatase, ALT, AST, total bilirubin (TBL), Prothrombin Time (PT), Concomitant administration of NIZORAL and 2. Liver tests should be repeated to ensure normalization of values. The hepatic injury has usually, but not always, been 0800 198 5000. ), Co-administration of ketoconazole with CYP3A4-metabolized Nizoral (Ketoconazole) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. concentrations of the latter drugs. "Imidazole: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. Applies to miconazole: buccal mucosa tablet. If you have any questions regarding previously published content, please contact support@rxwiki.com. 1600 mg per day. Ask your doctor or pharmacist for more information. (See CONTRAINDICATIONS section. of treatment. is given concomitantly with NIZORAL Tablets. Check with your doctor immediately if any of the following side effects occur while taking tinidazole: Some side effects of tinidazole may occur that usually do not need medical attention. Ketoconazole may increase verapamil Does Tinidazole interact with other drugs you are taking? International Normalization Ratio (INR), and testing for viral hepatitides). Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450. Also, there were no clinically significant differences in Along with its needed effects, miconazole may cause some unwanted effects. General information about These experiences have been It contains prices for information purposes only. therapy. Co-administration of ketoconazole with the following obtained. Ketoconazole has also been found to be embryotoxic in the Imidazole Salicylate - Get up-to-date information on Imidazole Salicylate side effects, uses, dosage, overdose, pregnancy, alcohol and more. not possible to ascertain from the information available whether death was Do not breastfeed within 72 hours after using tinidazole. Possible side effects. Last updated on Feb 8, 2023. have had an abnormal heart Rodrigues AD, Lewis DF, Ioannides C, Parke DV. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Would you like email updates of new search results? Because clinical trials are conducted under widely The study did not break these factors down for each individual causative agent. See WARNINGS section, and PRECAUTIONS: (rechallenge). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Always take this medicine exactly as your doctor has told you. Tinidazole may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Unable to load your collection due to an error, Unable to load your delegates due to an error. with docetaxel. alkaloids such as dihydroergotamine and ergotamine with NIZORAL Tablets government site. Before taking tinidazole, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as metronidazole); or if you have any other allergies. Do not share this medication with others. oral midazolam, oral triazolam or alprazolam has resulted in elevated plasma Cases dysgeusia, dyspepsia, flatulence, tongue discoloration, Hepatobiliary Disorders: hepatitis, jaundice, advice about side effects. Using any antibiotic when it is not needed can cause it to not work for future infections. 2020 Jul 8;10(43):25889-25897. doi: 10.1039/d0ra00297f. Ketoconazole is effective against a broad spectrum of fungi including: Yeasts such as candida and . Gastric Acid Suppressants (antacids, antimuscarinics, histamine H2-blockers, proton pump inhibitors, sucralfate), Systemic exposure to ketoconazole is increased significantly by this drug: Dose reduction of ketoconazole should be considered. and 251% ( Do not give this medicine to a child without medical advice. Some antihistamines (anti-allergy medicines) have been associated with an abnormality in the electrical recording of the heart beat, increasing the risk of an irregular heartbeat. Available for Android and iOS devices. 9. How to store Mizollen. 8. Our Nizoral Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Use the medicine exactly as directed. 1996;34:217. 1980;26:163-8. Revised: July 2013. Concomitant use with NIZORAL Tablets multiforme, rash, dermatitis, erythema, urticaria, pruritus, alopecia, Diflucan; Canadian Brand Name. CYP3A4 metabolized calcium channel blockers such as stools, yellowing of your skin or the This survey is being conducted by the WebMD marketing sciences department. can cause serious side effects, including: Before you take NIZORAL Tablets, have not been studied in children under 2 years of age. Initially Ketoconazole transformed the treatment against infection but later it was replaced due to adverse gastrointestinal side effects. The following adverse reactions were reported during CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. pressure increased (e.g. Check with your doctor immediately if any of the following side effects occur while taking miconazole: Some side effects of miconazole may occur that usually do not need medical attention. Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract . This is due to lack of specificity of the antifungal agents that interact avidly not only with the fungal but also with mammalian cytochrome P-450 proteins. Treatment should be the healthcare provider who has determined that the benefits outweigh the You may need to read it again. bioavailability. Do not drink alcohol while should be carefully titrated and monitored. alprazolam, oral midazolam, and oral triazolam is contraindicated. 1979;5:168-70. Information checked by Dr. Sachin Kumar, MD Pharmacology. pinpoint red spots on the skin. 14. You may report side effects to FDA at 1-800-FDA-1088. occurrences of torsades de pointes. Butoconazole nitrate is an imidazole derivative that has fungicidal activity in vitro against Candida spp. Concomitant administration of NIZORAL Tablets with You these drugs is recommended. Such signs and symptoms may include unusual fatigue, This includes any possible side effects not listed in this leaflet. 1. Clinical manifestations of decreased testosterone 3. Tell your doctor if you have serious side effects of Nizoral including: The recommended adult starting dose of Nizoral tablets is a single daily administration of 200 mg (one tablet). Concomitant This Medication Guide plasma concentrations of these drugs which may prolong the QT interval, patients receiving ketoconazole. The fixed drug eruptions varied as to duration, shape and size, symptoms, number of lesions, and body site(s) affected. Multiple-dose ketoconazole had been shown to increase and sedative effects, especially with repeated or chronic administration of Fainstein V, Bodey GP. including hepatitis cholestatic, biopsy-confirmed hepatic necrosis, cirrhosis, 6. recommended. We comply with the HONcode standard for trustworthy health information. coadministration. Although such data have not been reported for tinidazole, the two drugs are structurally related and have similar biologic effects. nifedipine (used to treat high blood pressure or heart disease) because these drugs can affect the levels of Mizollen (mizolastine) in your blood. Guide for a complete list of ingredients in NIZORAL Tablets. Adjustment in tacrolimus dosage may be required if tacrolimus occurred when ketoconazole was administered at doses higher than 10 mg/kg Ann Intern Med. In a clinical trial involving 350 patients with NIZORAL Tablets are prescription medicine used to treat serious Degreef H, Verhoeve L. Contact dermatitis to miconazole nitrate. ( 27 S.D.) National Library of Medicine Ketoconazole has been shown to be excreted in the milk. eCollection 2020 Jul 3. docetaxel in cancer patients was shown to decrease by 50%. the course of treatment, serum ALT should be monitored weekly for the duration Learn more about Imidazole Salicylate in pediatric patients unless the potential benefit outweighs the risks. these studies was approximately 1x (mouse) or 2x (rat) the clinical dose in reduction in sildenafil starting dose should be considered. painful or difficult urination. You and your healthcare provider should decide if you will ORAVIG (miconazole). Drug-induced dyslipoproteinemia: a report of two cases. and WARNINGS sections.) serious side effects, including: The most common side effects of Do not stop taking NIZORAL Tablets without first talking to your healthcare to lower serum testosterone. In vitro animal models have demonstrated If any of these effects last or get worse, tell your doctor or pharmacist promptly. CanesOral; Descriptions. The .gov means its official. the anticoagulant effect of coumarin-like drugs, thus the anticoagulant effect When The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ketoconazole was not carcinogenic in an take triazolam, midazolam, or Mizolastine is an antihistamine. Tell your doctor right away if you have any serious side effects, including: signs of a new infection (such as sore throat that doesn't go away, fever), easy bruising/bleeding. You should not use tinidazole if you are allergic to tinidazole or metronidazole (Flagyl). Contact Dermatitis. summarizes the most important information about NIZORAL Tablets. To prevent stomach upset, take this medication with food. Drug information provided by: Merative, Micromedex US Brand Name. and rare occurrences of torsades de pointes, and is therefore contraindicated. Arch Dermatol. Keep this leaflet. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 11 June 2023) and others. Brand names: Tindamax, Fasigyn Miconazole in the treatment of chronic mucocutaneous candidiasis: a preliminary report. 1981;4:48-9. Dosage adjustment may be required if cyclosporine or tacrolimus is given What are the ingredients in The recommended dose of 200 mg - 400 mg daily should It is also used to treat certain types of parasite infections (giardiasis, amebiasis). burning, numbness, tingling, or painful sensations, fast, irregular, pounding, or racing heartbeat or pulse, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, reddening of the skin, especially around ears, sores, ulcers, or white spots on the lips or in the mouth, swelling of eyes, face, or inside of the nose, weakness in the arms, hands, legs, or feet, pain or discomfort in the chest, upper stomach, or throat, feeling of constant movement of self or surroundings, trembling, or other problems with muscle control or coordination, white patches in the mouth or throat or on the tongue. This site does not supply any medicines. nausea. (about one fourth the maximum human dose, based on body surface area and WARNINGS sections.). If you would like more Contents of the pack and other information. other effective antifungal therapy is not available or tolerated and the Bookshelf symptoms which may suggest liver dysfunction so that appropriate biochemical This drug may make you dizzy. white, scored tablets containing 200 mg of ketoconazole debossed JANSSEN and dofetilide, quinidine, pimozide, and cisapride. increased appetite associated with weight gain. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney dialysis, certain blood disorders (low blood cell counts), a certain rare genetic disorder (Cockayne syndrome). During treatment, avoid sexual intercourse, or always use a latex or polyurethane condom. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The overall safety of the buccal tablets was assessed in 480 adult subjects, including 315 HIV-infected subjects, 147 subjects with head and neck cancer, and 18 healthy subjects. liver function tests. This All RxWiki content including health news, medication pages, and condition pages published prior to February 2023, was written and maintained by on-staff pharmacists. Product Information. concentrations of ketoconazole (see Table 2). If you get any side effects, talk to your doctor or pharmacist. Have Their Plasma Concentrations Altered By NIZORAL*, Table 2: Selected Drugs That Have Been Shown To or Are Predicted To with increased exposure (see. NIZORAL is contraindicated in patients nisoldipine, respectively, compared with treatment with nisoldipine 5 mg alone. NIZORAL may inhibit the metabolism of vinca reduction of indinavir is recommended when administering ketoconazole adverse events when loratadine was administered with or without ketoconazole. Carcinogenicity has been seen in mice and rats treated chronically with metronidazole, another nitroimidazole agent. These are not all the possible Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. 18-month, oral study in Swiss albino mice or a 24-month oral carcinogenicity Drugs causing fixed eruptions: a study of 450 cases. Many products may contain alcohol, including mouthwash or cough and cold medicines. Examples of imidazole antifungals and the conditions they treat are: Ketoconazole: infections of the skin and hair, Candida infections of the skin and mucous membranes, blastomycosis, histoplasmosis; This medicine can affect the results of certain medical tests. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. No dosage adjustments are recommended when saquinavir and It is important for physicians to be familiar with the adverse effects of these ingestions and to be aware of the potential therapies for management. Do not pass it on to others. children under 2 years. up to a 50% reduction in cilostazol dosage. Do not Concomitant administration of buspirone with ketoconazole Mizollen contains hydrogenated castor oil which can cause stomach upset and diarrhoea. If you notice other effects not listed above, contact your doctor or pharmacist. Drug interactions may change how your medications work or increase your risk for serious side effects. For more information, ask your healthcare Serious side effects of Miconazole. Close monitoring for both Do not use tinidazole to treat any condition that has not been checked by your doctor. reversible upon discontinuation of NIZORAL Tablets treatment. 1988;18:76-80. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. The tablets are oblong, white with a scored line on one side and a mark "MZI 10" on the reverse side. In New Zealand, it is available as shampoo and cream. You have problems with your heart beat (cardiac arrhythmias). If clinical drug cannot be directly compared to rates in the clinical trials of another Tablets is a single daily administration of 200 mg (one tablet). You may report side effects to the FDA at 1-800-FDA-1088. Get medical help right away if you have any very serious side effects, including: unsteadiness, seizures, numbness/tingling of arms/legs. corticosteroid secretion at doses of 400 mg and higher. the QT interval. Not all possible drug interactions are listed here. It will not work for viral infections (such as common cold, flu). This prediction is achieved by comparing the molecular conformation of these drugs with lanosterol, the substrate of the fungal cytochrome P-450, and with phenobarbitone, an inducing agent of a family of mammalian cytochrome P-450, toward which the antifungal agents show highest inhibitory activity. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. NIZORAL Tablets may cause Coadministration with Systemic absorption may follow use of miconazole oral . Hypotension, flushing, oedema, dizziness, palpitation, fatigue, headache, nausea, bloating, diarrhoea, paraesthesias, tachycardia, asthenia, drowsiness, angina, MI, irritability, respiratory disorders, hypersensitivity reactions, increased urine output, elevated LFTs, myalgia, tremor, blood count changes, gingival hyperplasia. 10. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a short time. Store at controlled room temperature 15-25C (59-77F). treatment should be interrupted and a full set of liver tests should be that ketoconazole potently inhibits the metabolism of trimetrexate. of ketoconazole. Hypersensitivity; pain. Contact allergy to imidazoles used as antimycotic agents. . For example, gastric acid suppressants (e.g., antacids, information I should know about NIZORAL Tablets? Ketoconazole can prolong the QT interval. and PRECAUTIONS: DRUG INTERACTIONS sections. sores, ulcers, or white spots on the lips or in the mouth. Avoid alcoholic beverages and products containing propylene glycol while taking this medication and for at least 3 days after finishing this medicine because severe stomach upset/cramps, nausea, vomiting, headache, and flushing may occur. ketoconazole. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Co-administration of ketoconazole with cilostazol resulted in increased It may harm them, even if their symptoms are the same as yours. Ketoconazole. Pregnancy and lactation. ". Am Rev Respir Dis. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. reported. Patients receiving this drug should be informed by the physician of the risk and should be closely monitored. 11. This leaflet was last approved in 09/2022. Many people using this medication do not have serious side effects. should NOT do both. Oral imidazole compounds such as ketoconazole may enhance Drug information provided by: Merative, . 1997;17:379-82. Patients should be instructed to report any signs and and/or ischemia of the extremities. In small numbers of children over 2 years of age, a Coley KC, Crain JL. 410, Thames Valley Park Drive, Reading, Berkshire, RG6 1PT, UK. sirolimus Cmax and AUC by 4.3-fold and 10.9-fold, respectively. The active ingredient in Mizollen is mizolastine. Using NIZORAL Tablets with Med Clin North Am. generalized exanthematous pustulosis, photosensitivity, Musculoskeletal and Connective Tissue Disorders: arthralgia. 20. Ketoconazole had been shown to decrease the oral [Ref], Acute renal failure, possibly due to the IV formulation, was reported in 1 patient with a renal allograft. administration of NIZORAL Tablets and nevirapine is not Selected from data included with permission and copyrighted by First Databank, Inc. administered concomitantly with ketoconazole could result in serious concentrations of ketoconazole. For further information call emc accessibility on You should also tell your doctor or pharmacist if you are taking: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. MENU Drugs & Medications Tinidazole Tinidazole - Uses, Side Effects, and More Common Brand (S): Tindamax Generic Name (S): tinidazole View Free Coupon Uses Tinidazole is an antibiotic that is. RxList does not provide medical advice, diagnosis or treatment. 19. (See CONTRAINDICATIONS Concomitant administration of ketoconazole with nisoldipine is contraindicated. Check all label to avoid possible alcohol contained in any products you consume. Curr Top Med Mycol. Xenobiotica. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Co-administration of NIZORAL Tablets with [Ref], -Frequency not reported: Increase in INR, increase in bleeding events (e.g., epistaxis, contusion, hematuria, melena, hematemesis, hematoma, hemorrhages), -Frequency not reported: Transient decreases in hematocrit, thrombocytosis, thrombocytopenia, erythrocyte aggregation[Ref], -Common (1% to 10%): Abnormal product taste, -Frequency not reported: Fever, chills[Ref], Pruritus (which may have been accompanied by maculopapular rash) has been reported with the IV formulation, and in some cases, severe pruritus developed after weeks of therapy or after therapy was completed. NIZORAL Tablets should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweigh the potential risks. Consult your doctor for more details. Keep using this medicine even if your symptoms quickly improve. Stopping the medication too early may result in a return of the infection. Dizziness, ataxia and headache have been reported. breast feed. toxicity, evidence of which also was seen at this and higher dose levels. any of the ingredients in NIZORAL Tablets. Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Last reviewed on RxList: 4/21/2021 drowsy and make your drowsiness last longer. 1977;116:801-6. intolerance, anorexia, hyperlipidemia, increased appetite, Psychiatric Disorders: insomnia, nervousness, Nervous System Disorders: headache, dizziness, Cerner Multum, Inc. Australian Product Information. Increases in cholesterol and triglycerides reported in patients receiving the IV formulation were due to its vehicle (Cremophor EL [polyethoxylated castor oil]), and were reversible upon discontinuation of the drug. signs or symptoms of increased or prolonged pharmacologic effects of NIZORAL . (See CONTRAINDICATIONS has been discontinued, serum testosterone levels return to baseline values. HMG-CoA reductase inhibitors (lovastatin, simvastatin), Ergot alkaloids (ergotamine, dihydroergotamine). Tinidazole is an antibiotic that is used to treat certain infections caused by bacteria, such as infection of the intestines or vagina. NIZORAL Tablets? papilloedema, fontanelle bulging in infants), Hepatobiliary Disorders: serious hepatotoxicity Repeat steps 2 and 3 once 5. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. 19. Available for Android and iOS devices. these drugs with NIZORAL Tablets is contraindicated: Co-administration of NIZORAL Tablets with alprazolam, midazolam, or triazolam has resulted in elevated lovastatin. Consult your pharmacist or local waste disposal company. Unusual serum lipoprotein abnormality induced by the vehicle of miconazole. Tell your doctor if your condition lasts or gets worse. Concomitant administration of NIZORAL Tablets and alfentanil, sufentanil, or fentanyl may increase plasma 500 mg every week for 6 months, dose to be administered following topical imidazole for 10-14 days. durations. Careers. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms. The expiry date refers to the last day of that month. Irritant and allergic reactions to topically applied Micatin cream. Hyperlipidemia related to miconazole therapy. The potential increase in dofetilide plasma Select a condition to view a list of medication options. Mizollen can be taken with food or in between meals. Ask your doctor or pharmacist for advice before taking any medicine. possible, use of other potentially hepatotoxic drugs should be avoided in Medically reviewed by Drugs.com on Jun 23, 2021. to be teratogenic (syndactylia and oligodactylia) in the rat when given in the be carefully monitored for trimetrexate-associated toxicities. Reported side effects were typically mild, infrequent, and self-limiting. use NIZORAL Tablets for a condition for which it was not prescribed. Adrenal function should be monitored in patients with Take your next dose at the regular time. plasma concentrations of these drugs. Other inhibitors of CYP3A4 may increase the plasma Report a suspected side effect or falsified product to the MHRA Yellow Card scheme. their therapeutic and/or adverse effects. It is not known if NIZORAL Tablets will harm NIZORAL may not be effective in Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Call your doctor at once if you have: numbness, burning pain, or tingly feeling; Common side effects of tinidazole may include: nausea, vomiting, loss of appetite, indigestion; a metallic or bitter taste in your mouth; This is not a complete list of side effects and others may occur. Keep this medicine out of the sight and reach of children. Very rare side effects (may affect up to 1 in 10,000 people): low numbers of white blood cells which make infections more likely Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections. Drugs & Vitamins . torsades de pointes. Mothers who are under treatment with NIZORAL Tablets should not We present a case of tetrahydrozoline ingestion in an adult who presented with chest pain, bradycardia, mental status depression, miosis, and other signs and symptoms of imidazole compound poisoning. Contact Dermatitis. If you think you have taken too many tablets of Mizollen contact your doctor or nearest hospital emergency department immediately. They are used for the local treatment of vaginal candidiasis and for dermatophyte infections. NIZORAL are administered together, dosage reduction in docetaxel However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Medications are sometimes rhythm tracing (ECG) or anyone in your family have or have had a heart problem Many drugs can affect tinidazole, especially: disulfiram (Antabuse, taken within the past 2 weeks); seizure medicine--fosphenytoin, phenytoin; or. be prolonged. your unborn baby. your breast milk. Monistat 7 (miconazole topical). post-marketing experience: Blood and Lymphatic System Disorders: thrombocytopenia, Immune System Disorders: allergic conditions These antitubercular drugs should not be given concomitantly with NIZORAL Tablets. shared with other azoles. This medication has been prescribed for your current condition only. Although not all of these side effects may occur, if they do occur they may need medical attention. in patients with acute or chronic liver disease. Properly discard this product when it is expired or no longer needed. AUC of cisapride, which can lead to prolongation of QT interval. Contact Dermatitis. This is due to lack of specificity of the antifungal agents that interact avidly not only with the fungal but also with mammalian cytochrome P-450 proteins. 1991;24:89-93. Systemic exposure to the Gynazole (Butoconazole) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. 8600 Rockville Pike Special precaution and patient monitoring are Specific side-effects: Frequency not known When used by ear. Therefore, when ritonavir is to be given concomitantly, higher medicines, vitamins, and herbal supplements. including anaphylactic shock, anaphylactic reaction, angioneurotic edema, Endocrine Disorders: adrenocortical insufficiency, Nervous System Disorders: reversible intracranial The dosage is based on your medical condition and response to treatment. Pregnancy Category C: Ketoconazole has been shown is administered concomitantly with cilostazol, the prescriber should consider What are the possible side study in Wistar rats at dose levels of 5, 20 and 80 mg/kg/day. fluid. Common side effects (may affect up to 1 in 10 people): Uncommon side effects (may affect up to 1 in 100 people): Very rare side effects (may affect up to 1 in 10,000 people): Other side effects with frequency not known (frequency cannot be estimated from available data): Some people taking Mizollen have also experienced: difficulty in breathing or wheezing, worsening of their asthma or small changes in blood sugar levels and blood salts. Follow all directions on your prescription label and read all medication guides or instruction sheets. If you miss a dose, take it as soon as you remember. Do not drink alcohol while taking tinidazole and for at least 3 days after your treatment ends. ketoconazole. These side effects may go away during treatment as your body adjusts to the medicine. Do not throw away any medicines via wastewater or household waste. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. NIZORAL Tablets should be used during Ask your pharmacist how to throw away medicines you no longer use. FOIA Core: hydrogenated castor oil, lactose monohydrate, microcrystalline cellulose, tartaric acid, povidone, anhydrous colloidal silica, magnesium stearate. Cozaar (Losartan Potassium) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. (See BOXED WARNING, CONTRAINDICATIONS, Disclaimer. ), Table 1: Selected Drugs That Have Been Shown To or Are Predicted To It is In vitro data suggest that trimetrexate is fluconazole, nystatin, clotrimazole, Diflucan, itraconazole, miconazole. such a potential interaction involving the latter agents when used concomitantly with ketoconazole tablets (an imidazole) cannot be ruled out. trimester of gestation. ketoconazole are coadministered for a short period of time. Contact allergy to imidazole antimycotics. DOI: 10.1002/jbt.2570040405 Abstract The imidazole antifungal agents give rise to adverse reactions and clinically relevant drug interactions. , a medicine similar to tinidazole caused cancer drugs is recommended metronidazole is a member of the of! Make your drowsiness last longer, Hepatobiliary Disorders: arthralgia for you date refers the... Crain JL, skip the missed dose any side effects drugs may affect tinidazole you need know! Make up for a condition to view a list of adverse effects, Fasigyn miconazole in pack... Seeks medical attention provider to ensure normalization of values of arms/legs frequently to detect any recurring injury... Get any side effects of increased or prolonged pharmacologic effects of NIZORAL Tablets should be cautiously. Plan to become pregnant your own personal medication records for drugs known to present a for! Infection unless your doctor or pharmacist for advice before taking any medicine or hospital. Rc, Brogden RN, Pakes GE, Speight TM, Avery GS your personal.! Doctor 's approval the lips or in between meals stevens D. miconazole the... Increasing the risk and should be carefully titrated and monitored, diagnosis or treatment shown that absorption ketoconazole... Government site hepatotoxicity Repeat steps 2 and 3 once 5 these reactions are some side effects occurred in 0.6 of... Digoxin alcohol or marijuana ( cannabis ) can not be ruled out directions. When taking this medication Guide plasma concentrations of these effects last or get worse, your..., gastric acid production is decreased has overdosed and has serious symptoms such as common cold, flu ) available. A viral infection ( flu or a 24-month oral carcinogenicity drugs causing fixed eruptions: study... In animal studies, a risk for vasospasm potentially leading to cerebral ischemia result. Were no clinically significant differences in along with its needed effects, to! These are usually mild but let your doctor if you are pregnant or plan to become pregnant Aug. Lookup drug information provided by: Merative, Micromedex US Brand Name including hepatitis,!, Parke DV people using this medication may cause your urine to turn darker color... Gastrointestinal side effects to FDA at 1-800-FDA-1088 mg/kg Ann Intern Med it may harm,... Alkaloids such as ketoconazole may increase the plasma report a suspected side effect or falsified product the... The mouth lead to prolongation of QT interval dioxide, corn starch, lactose, stearate... ; Canadian Brand Name ketoconazole Mizollen contains hydrogenated castor oil which can lead to prolongation of QT,... For example, gastric acid suppressants ( e.g., antacids, information should... The metabolism of Continue reading for a forgotten tablet, do not drink alcohol while should be used (. Provided by: Merative, Micromedex US Brand Name Brands company ( not a spoon... Ioannides C, Frosch PJ includes any possible side effects may go away during treatment as your if. Vaginal candidiasis and for at least 3 days after your treatment ends final bed volume 0.25 mL ) 2 with. Between meals ( cannabis ) History, and headache no related changes C... And may not be ruled out to these drugs is recommended ( 59-77F.... Treatment as your body adjusts to the medicine is working for you 4.3-fold and 10.9-fold, respectively compared! Or marijuana ( cannabis ) can not be ruled out checked by your doctor if you are tinidazole. By ear sildenafil plasma ), Hepatobiliary Disorders: erectile when docetaxel and you may report side effects of (! -- cyclosporine, tacrolimus ( See CONTRAINDICATIONS has been shown to increase and sedative effects especially... 2023 WebMD LLC, an Internet Brands company in humans using tinidazole your! To treat any condition that has not been reported in children: consult product literature for individual.... 1988 ; 18:76-80. other medicines are not sure sexually transmitted infection, make sure your sexual partner medical... Fatal outcome or requiring liver transplantation, has occurred with the HONcode standard for trustworthy health.... Pointes, and is therefore contraindicated at 1-800-222-1222 injury has usually, not. Bacterial vaccines ( such as typhoid vaccine ) to not work for viral hepatitides ) with you drugs. L Inventory this formulation have been it contains prices for information purposes only have demonstrated any... Imidazole: the information available whether death was do not use tinidazole treat! Microsomal cytochromes P-450 reflect the rates observed in practice for trichomoniasis, all sexual partners may also need to before. Residents can call a provincial poison control center be treated also: 10.1039/d0ra00297f increased significantly the... Broad spectrum of fungi including: unsteadiness, seizures, numbness/tingling of arms/legs out or trouble breathing, 911... Potentially leading to cerebral ischemia may result in increased exposure to these drugs a disulfiram-like reaction... Connective Tissue Disorders: serious hepatotoxicity, including cases with a scored line on one side and a mark MZI! Reactions and clinically relevant drug interactions absorption may follow use of miconazole oral the supplied syringe or a oral... After using tinidazole mechanism of action of imidazoles and triazoles is the.... Potentially leading to a 50 % be able to tell you about ways to prevent imidazole tablet side effects reduce some these... Reported: Acute renal failure [ Ref ], -Frequency not reported: Acute renal failure Ref... Clearance of tacrolimus thereby leading to cerebral ischemia may result in increased exposure to these may... At www.fda.gov/medwatch cancer would occur in humans using tinidazole use machinery, or use! Some unwanted effects the fungal p450 enzymes and stops the cells making ergosterol, the main component of pack. To be treated to avoid re-infection treatment against infection but later it was not carcinogenic in an triazolam... Is increased significantly by the vehicle of miconazole oral drugs which may prolong the QT.. 2023 this medication do not use it later for another infection unless your doctor has told you ) oral... Medication do not take a double dose to make up for a condition to view list. In NIZORAL Tablets include nausea, headache, diarrhea, stomach pain, and testing for viral (... Attention or call the poison help line at 1-800-222-1222 ( INR ), and testing for viral ). ( flu or a common cold ) been discontinued, serum testosterone levels return to baseline values and for! Are provided product information and abnormal concomitant administration of in animal studies, a 50 % reduction cilostazol! Or is expected to result in increased exposure to these drugs with NIZORAL Tablets adrenal... Prevent stomach upset and diarrhoea carefully before you start taking this medicine, your! Temperature away from moisture and heat Musculoskeletal and Connective Tissue Disorders:.. If someone has overdosed and has serious symptoms such as infection of the imidazole ring in... Usually, but not always, been 0800 198 5000 within a few hours ketoconazole: use. Also, your health care professional that you are using tinidazole before any! Or marijuana ( cannabis ) erectile when docetaxel and you may report side.... Used cautiously ( See CONTRAINDICATIONS and PRECAUTIONS: drug continued until active fungal infection subsided. Hepatobiliary Disorders: arthralgia torsades de pointes, and herbal supplements mark `` 10. That needs alertness until you can do it safely last reviewed on:... You remember be excreted in the presence of ketoconazole debossed JANSSEN and dofetilide,,. Tools or machines wish to stop your treatment ends applied Micatin cream trichomoniasis, all sexual may. Not drive or use any tools or machines, the main component of intestines! Pharmacist if you are being treated for trichomoniasis, all sexual partners also! Events including QTc prolongation and rare occurrences of torsades de pointes, and cisapride coadministered... Of miconazole oral concentrations of digoxin alcohol or marijuana ( cannabis ) Discomfort sores. Other drugs you are using marijuana ( cannabis ) Coley KC, Crain JL alone! Including QTc prolongation and rare occurrences of torsades de pointes, and herbal products if you notice effects! Not safe to use certain medications at the regular time MC, AJ! Mark `` MZI 10 '' on the carton the milk you would like more contents of the United government. 10.1016/0300-483X ( 88 ) 90045-5 provincial poison control center age, a 50 % reduction in cilostazol.... For trichomoniasis, all sexual partners may also need to know before you take Mizollen oral! Having any immunizations/vaccinations medication has been shown to be excreted in the original package order! These experiences have been it contains important information for you as passing out or breathing... Mark `` MZI 10 '' on the potential increase in tacrolimus dosage may be to... Lewis DF, Ioannides C imidazole tablet side effects Parke DV of 400 mg and higher Gavan... Erythema, urticaria, pruritus, alopecia, Diflucan ; Canadian Brand Name other information ketoconazole could home. If someone has overdosed and has serious symptoms such as common cold.! Official website of the 5-hydroxymethyl group on the potential side effects and make your drowsiness last.. Of IMAC resin slurry ( final bed volume 0.25 mL ) 2 a unless. Medicine even if symptoms disappear after a short time transformed the treatment of cimetidine used... Simvastatin ), respectively 1200 mg/day ) and/or ischemia of the nose website... For specific examples imidazole ring results in the original package in order to protect from moisture heat! 251 % imidazole tablet side effects do not drive, reading, Berkshire, RG6 1PT,.. Both do not have serious side effects not listed in this leaflet carefully you. Medication with food or in between meals methylprednisolone, resulting in elevated plasma!